Exclusion Criteria

  • Patient is < six years of age
  • No history of previous cold sore
  • HIV infection
  • Immunosuppression
  • Meningitis symptoms (headache, fever, fatigue, nausea, vomiting, light sensitivity, neck stiffness, pain)
  • Ocular symptoms (blurry vision, excessive tearing, eye pain)
  • Pharyngitis (difficulty swallowing, throat pain)
  • Pregnancy
  • More than six episodes in the last 12 months
  • Lesions not on the vermillion border of the lip or elsewhere on the body
  • A continuation of a previous episode that has not healed 
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